ç£å»çã§äžè¬çã«è¡ãããŠããã¯ãã¹ãããã¯ãäž»ã«IgMã«ããäžé©å茞è¡ãé²ãç®çã§è¡ãããŠããŸããäžæ¹ãå»çã§ã¯IgGã«ããäžé©å茞è¡ãåé¿ããç®çã§ãã¯ãŒã ã¹è¡æž ãçšããŠæ€æ»æ床ãé«ãããéæ¥æã°ãããªã³è©ŠéšããããããŠå®æœããŠããŸãããªãã¯ãŒã ã¹è¡æž ãçšãããã¯çããŸãåãã®ããšãšæãããŸãããIgGåäœã§ã¯èµ€è¡çåéãåŒãèµ·ããããšãã§ããªãïŒã¯ãã¹ãããã§æ€åºã§ããªããšãããŠããããã§ãã
éå»ã®Journal clubã§ãç¬ã®ã¯ãã¹ãããã§éæ¥æã°ãããªã³è©Šéšãå®æœããŠããæç®ã玹ä»ããŠããŸããããéæ¥æã°ãããªã³è©Šéšãç¬ã«ãå¿ èŠãªã®ãã©ãããçç®ããç 究ã¯ãããŸã§ã¿ãããŸããã§ãããããã§ä»å玹ä»ããæç®ã¯ãDEA1é©å茞è¡ãåããããšã®ããç¬ã®ã¯ãã¹ãããã«ãããŠãã¯ãŒã ã¹è¡æž ãçšããå ŽåïŒéæ¥æã°ãããªã³è©ŠéšïŒãšçšããªãå ŽåïŒåŸæ¥æ³ïŒã§ã©ã®ããã«çµæãç°ãªãã®ãã«ã€ããŠèª¿ã¹ãŠããŸãã
çµæãã©ã¡ããçæ¹ã ãè¡ãã°è¯ããšããèš³ã§ã¯ãªããåŸæ¥æ³ãšéæ¥æã°ãããªã³è©Šéšã®äž¡è ãè¡ã£ãæ¹ãã¯ãã¹ãããã®æ床ãé«ãŸãå¯èœæ§ãææãããŠããŸãããã¡ãããä»åã®ç 究ãIn vitroã®ãã®ã§ãããããéæ¥æã°ãããªã³è©Šéšã§ã®ã¿æ€åºãããäžé©åã®çµã¿åããã§èŒžè¡ããå Žåã«ã©ã®ãããªèŒžè¡åå¿ãèµ·ããã®ãããã®ç¹ã¯æªè§£æã§ããããšã念é ã«çœ®ãå¿ èŠããããŸãããªãŒãã³ã¢ã¯ã»ã¹ã®æç®ãªã®ã§ãã²åæãšããããŠã芧äžããã
ïŒæ åœ: ç¬å·ïŒ
茞è¡æŽã®ããç¬ã«ãããŠã¯ãŒã ã¹è¡æž ãã¯ãã¹ãããã®æ床ã«äžãã圱é¿ã®è©äŸ¡
èè : Alison Thomas-Hollands, Rebecka S Hess, Nicole M Weinstein, Samantha Fromm, Nicole A Chappini, Kimberly Marryott, Mary Beth Callan.
æ²èŒèª: J Vet Diagn Invest. 2024 Jan 11. Online ahead of print. PMID: 38212878
èæ¯ãšç®ç: ã¯ãã¹ãããã¯ãç¹ã«èŒžè¡æŽã®ããç¬ã«å床茞è¡ãè¡ãäžã§ã¯å¿ é ã®æ€æ»ã§ãããå€ãã®å€§åŠéå±åç©ç é¢ãäºæ¬¡èšºçæœèšã§ã¯è©Šéšç®¡åéæ³ãããã¯ã²ã«ã«ã©ã æ³ã«ããã¯ãã¹ããããè¡ã£ãŠããããæšæºçãªæ¹æ³ã¯ããŸã ã«ç¢ºç«ãããŠããªããããã«ã¯ãŒã ã¹è¡æž ãçšããããšã§ã¯ãã¹ãããã®æ床ãåäžããããšã¯ç€ºåãããŠããããå®éã®ãšããã¯æªè§£æã§ãããããã§æ¬ç 究ã¯ãDEA1é©å茞è¡æŽã®ããç¬ã«ãããŠãã¯ãŒã ã¹è¡æž ãçšããã¯ãã¹ãããïŒéæ¥æã°ãããªã³è©ŠéšïŒãšããã§ãªãã¯ãã¹ãããïŒåŸæ¥æ³ïŒã§çµæãç°ãªãã®ããè©äŸ¡ããããšãç®çãšããã
æ¹æ³: 33é ã®çäŸç¬ãã茞è¡åããã³èŒžè¡åŸã®æ€äœãæ¡åãããããŒ1-6é ïŒäžå€®å€3é ïŒãšã²ã«ã«ã©ã æ³ã«ããã¯ãã¹ãããã®äž»è©Šéšãè¡ã£ããçµæçã«éæ¥æã°ãããªã³è©ŠéšãšåŸæ¥æ³ããããã202件å®æœãã4åã®è©äŸ¡è ã«ãã£ãŠå€å®ããããªãããã®ãã¡3åã¯ãããããã©ã®ãããªãµã³ãã«ãåãããªãããã«å¿ååãããç¶æ ã§è¡ã£ãã
çµæ: çäŸç¬33é äž10é ïŒ30%ïŒã§èŒžè¡åŸã®æ€äœã«ãããŠã¯ãã¹ãããäžé©åãèªããããããã«ãªã£ããããã®ãã¡4é ã¯éæ¥æã°ãããªã³è©Šéšã®ã¿ã3é ã¯åŸæ¥æ³ã§ã®ã¿äžé©åãã¿ãããããããŠæ®ãã®3é ã¯ãããã®æ¹æ³ã«ãããŠãäžé©åãæ€åºãããããªããéæ¥æã°ãããªã³è©ŠéšãšåŸæ¥æ³ã¯é©åã«ãããŠÏ=0.34ïŒp<0.001ïŒãäžé©åã«ãããŠÏ=0.35ïŒp<0.001ïŒçšåºŠã®æ£ã®çžé¢ãèªããããããŸãã4åã®è©äŸ¡è éã®çµæã®è§£éã«ã°ãã€ãã¯å°ãªããé©åã«ãããŠÎº=0.97ïŒp<0.001ïŒãäžé©åã«ãããŠÎº=0.77ïŒp<0.001ïŒã®é«ãäžèŽçã瀺ããŠããã
çµè«: ã²ã«ã«ã©ã æ³ã«ããã¯ãã¹ãããã®æ床ãæ倧éé«ããããã«ã¯ãåŸæ¥æ³ã«å ããŠéæ¥æã°ãããªã³è©Šéšãè¡ãã¹ããšç€ºåãããã